Lipid Nanoparticles

Among our specialty focuses at Exelead is the development and manufacturing of lipid nanoparticles (LNP).

While similar by design to liposomes, lipid nanoparticles are slightly different in composition and function. Both are excellent drug delivery vehicles, transporting cargo of interest within a protective, outer layer of lipids. In application, however, LNP’s can take a variety of forms.

LNPs are liposome-like structures especially geared towards encapsulating a broad variety of nucleic acids (RNA and DNA).

As such, they are the most popular non-viral gene delivery system. Exelead develops and manufactures LNPs to encapsulate different types of genetic payloads, including siRNA, mRNA, and saRNA.

Traditional liposomes include one or more rings of lipid bilayer surrounding an aqueous pocket, but not all LNPs have a contiguous bilayer that would qualify them as lipid vesicles or liposomes. Some LNPs assume a micelle-like structure, encapsulating drug molecules in a non-aqueous core.

Regardless of structure, LNP’s have become a crucial component of development and manufacturing in the biopharmaceutical world. With our team’s knowledge and experience in liposomal technology, we can help your drug product from its early stage beginnings to clinical supply to its successful commercial manufacturing.